PROTALIX BIOTHERAPEUTICS INC
 
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To the Shareholders of PROTALIX BIOTHERAPEUTICS INC,

The 2009 Annual Meeting of Shareholders of PROTALIX BIOTHERAPEUTICS INC will be held on November 9, 2009 for shareholders of record as of September 15, 2009.

Your vote is important, so please vote at your earliest convenience.

If you are a registered holder to vote your proxy online or by telephone you will need your account's unique 11-digit Control Number, which is located in your proxy e-mail or located beneath the company and account number on the upper-right side of your proxy material.

To vote online, please click "Vote Your Online Proxy”.

To vote by telephone, call toll-free 1-800-PROXIES (1-800-776-9437) in the United States or 1-718-921-8500 from foreign countries and follow the instructions.

If you own shares through a broker please follow the instructions that were provided to you by your broker/financial institution.

If you have any questions, please contact American Stock Transfer & Trust Company, LLC.



Thank you,

American Stock Transfer & Trust Company, LLC
Transfer Agent for PROTALIX BIOTHERAPEUTICS INC


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